MovDisordV3, Main, Exploration, bibRecord, 003477

Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration

Identifieur interne : 003477 ( Main/Exploration ); précédent : 003476; suivant : 003478

Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration

Auteurs : Stefanie Klaffke [Allemagne] ; Andrea A. Kuhn [Allemagne] ; Michail Plotkin [Allemagne] ; Holger Amthauer [Allemagne] ; Daniel Harnack [Allemagne] ; Roland Felix [Allemagne] ; Andreas Kupsch [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-10.

RBID : ISTEX:5EDB647FA497F028DFB22DE1DDE0A9CC11B5E305

Descripteurs français

Pascal (Inist)
- Dégénérescence, Glucose, Métabolisme, Parkinson maladie, Photon, Positon, Récepteur dopaminergique D2, Système nerveux pathologie, Tomographie émission positon, Tomoscintigraphie émission monophotonique.
Wicri :
- topic : Glucose.

English descriptors

KwdEn :
- Aged, Benzamides (diagnostic use), Blood Glucose (metabolism), Brain (physiopathology), Brain (radionuclide imaging), Cerebral Cortex (physiopathology), Cerebral Cortex (radionuclide imaging), Cocaine (analogs & derivatives), Cocaine (diagnostic use), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), D2 Dopamine receptor, Degeneration, Dominance, Cerebral (physiology), Female, Fluorodeoxyglucose F18 (diagnostic use), Glucose, Humans, Male, Metabolism, Middle Aged, Nervous system diseases, PET, Parietal Lobe (physiopathology), Parietal Lobe (radionuclide imaging), Parkinson disease, Parkinsonian Disorders (physiopathology), Parkinsonian Disorders (radionuclide imaging), Photon, Positron, Positron emission tomography, Positron-Emission Tomography, Pyrrolidines (diagnostic use), Receptors, Dopamine D2 (physiology), SPECT, Single photon emission tomography, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), atypical parkinsonian syndromes, corticobasal degeneration.
MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , diagnostic use : Benzamides, Cocaine, Fluorodeoxyglucose F18, Pyrrolidines, Tropanes.
- chemical , metabolism : Blood Glucose.
- physiology : Dominance, Cerebral, Receptors, Dopamine D2.
- physiopathology : Brain, Cerebral Cortex, Corpus Striatum, Parietal Lobe, Parkinsonian Disorders.
- radionuclide imaging : Brain, Cerebral Cortex, Corpus Striatum, Parietal Lobe, Parkinsonian Disorders.
- Aged, Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon.

Abstract

Alterations in presynaptic and postsynaptic dopaminergic system and cerebral glucose metabolism in corticobasal degeneration (CBD) were assessed to evaluate the potential usefulness of different imaging methods for CBD. 123I‐FP‐CIT/123I‐β‐CIT SPECT and 123I‐IBZM SPECT as well as 18F‐FDG PET were performed in eight CBD patients. Decreased presynaptic dopamine transporter binding was found in all CBD patients while D2 receptor binding was reduced in only one patient. 18F‐FDG PET displayed a contralateral hypometabolism in cortical and subcortical areas in seven out of eight patients. Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/5EDB647FA497F028DFB22DE1DDE0A9CC11B5E305/fulltext/pdf

DOI: 10.1002/mds.21004

Affiliations:

Le document en format XML

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<term>Brain (radionuclide imaging)</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>Cocaine (analogs & derivatives)</term>
<term>Cocaine (diagnostic use)</term>
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<term>Single photon emission tomography</term>
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<term>Fluorodeoxyglucose F18</term>
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<term>Receptors, Dopamine D2</term>
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<term>Corpus Striatum</term>
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<term>Corpus Striatum</term>
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<term>Parkinsonian Disorders</term>
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<front><div type="abstract" xml:lang="en">Alterations in presynaptic and postsynaptic dopaminergic system and cerebral glucose metabolism in corticobasal degeneration (CBD) were assessed to evaluate the potential usefulness of different imaging methods for CBD. 123I‐FP‐CIT/123I‐β‐CIT SPECT and 123I‐IBZM SPECT as well as 18F‐FDG PET were performed in eight CBD patients. Decreased presynaptic dopamine transporter binding was found in all CBD patients while D2 receptor binding was reduced in only one patient. 18F‐FDG PET displayed a contralateral hypometabolism in cortical and subcortical areas in seven out of eight patients. Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD. © 2006 Movement Disorder Society</div>
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Movement Disorders (revue)

Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration

Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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